Faculty & Staff
Jiali Han, PhD
Efroymson Professor in Cancer Research, Co-leader, Cancer Prevention & Control Pgm, Simon Cancer Center
Dr. Han is interested in understanding the influence of genetic and environmental factors on the etiology and prevention of skin lesions. His genetic epidemiological research started with the etiology of skin cancers and expanded to other skin lesions such as psoriasis, moles, and acne. Besides a series of genetic susceptibility investigation, he has also conducted a great deal of epidemiological research to identify lifestyle and environmental risk factors and comorbidities for skin cancers, psoriasis, and acne. Currently he leads post-GWAS collaborative projects examining the biological function of genetic variants using bioinformatics and molecular biology tools. In addition to a series of newly identified genetic markers for human pigmentation and skin cancers, he recently has conducted cancer network research.
He has also played a leading role in large national and international collaborative consortia on melanoma, non-melanoma skin cancer, and human pigmentation. He has also worked on breast, endometrial and lung cancers. In addition, he serves as a key investigator on multiple NIH-funded projects, providing critical expertise in genetic and molecular epidemiology to other faculty members and researchers. He has been the Principal Investigator on a dozen of NIH grants. He has published over 160 original research articles in peer-reviewed journals. He has been invited to speak about his research at regional, national, and international scientific meetings. He has served as ad hoc reviewer for over 100 peer-reviewed scientific journals and is currently an Associate Editor for the journal Cancer Causes and Control. He also serves on the editorial board of Experimental Dermatology and has acted as Guest Associate Editor of PLoS Genetics. Dr. Han has served on a number of national and international committees and grant review panels in the NIH study sections, the U.S. Department of Defense, and the American Cancer Society. He has been on several committees and chaired sessions of national and international scientific societies.
Selected publications (from over 160 original articles)
Han J, Kraft P, Nan H, Guo Q, Chen C, Qureshi A, Hankinson SE, Hu FB, Duffy DL, Zhao ZZ, Martin NG, Montgomery GW, Hayward NK, Thomas G, Hoover RN, Chanock S, Hunter DJ. A genome-wide association study identifies novel alleles associated with hair color and skin pigmentation. PloS Genetics. 2008 May 16;4(5):e1000074.
Schernhammer ES, Razavi P, Li TY, Qureshi AA, Han J. Rotating night shifts and risk of skin cancer in the Nurses’ Health Study. J Natl Cancer Inst. 2011 Apr 6; 103(7): 602-6.
Nan H, Du M, De Vivo I, Manson JE, Liu S, McTiernan A, Curb JD, Lessin L, Bonner MR, Guo Q, Qureshi AA, Hunter DJ, Han J. Shorter telomeres associate with a reduced risk of melanoma development. Cancer Res. 2011;71:6758-63.
Zhang M, Qureshi AA, Geller AC, Frazier L, Hunter DJ, Han J. Use of tanning beds and incidence of skin cancer. J Clin Oncol. 2012 May 10;30(14):1588-93. An invited editorial accompanying the article (1571-73).
Song F, Qureshi AA, Han J. Increased caffeine intake is associated with reduced risk of basal cell carcinoma of the skin. Cancer Res. 2012 Jul 1;72(13):3282-9.
Shoag J, Haq R, Zhang M, Liu L, Rowe GC, Jiang A, Koulisis N, Farrel C, Amos CI, Wei Q, Lee JE, Zhang J, Kupper TS, Qureshi AA, Cui R, Han J*, Fisher DE*, Arany Z* (*co-senior authors). PGC-1 coactivators regulate MITF and the tanning response. Mol Cell. 2013 Jan 10;49(1):145-57.
Song F, Qureshi AA, Giovannucci E, Fuchs C, Chen W, Stampfer MJ, Han J. Non-melanoma skin cancer and risk of second primary cancer. PLoS Med. 2013;10(4):e1001433.
Zhang M, Song F, Liang L, Nan H, Zhang J, Liu H, Wang L, Wei Q, Kraft P, Qureshi AA, Han J. Genome-wide association studies identify several new loci associated with pigmentation traits and skin cancer risk in European Americans. Hum Mol Genet. 2013 Jul 15;22(14):2948-59.
Bao Y, Han J, Hu FB, Giovannucci EL, Stampfer MJ, Willett WC, Fuchs CS. Association of nut consumption with total and cause-specific mortality. N Engl J Med. 2013 Nov 21; 369 (21): 2001-11.
Li W, Qureshi AA, Ma J, Goldstein AM, Giovannucci E, Stampfer MJ, Han J. Personal history of prostate cancer and increased risk of incident melanoma in the United States. J Clin Oncol. 2013 Dec 10;31(35):4394-9.
Li W, Qureshi AA, Robinson K, Han J. Sildenafil use and increased risk of incident melanoma in US men: a prospective cohort study. JAMA Intern Med. 2014 Jun;174(6):964-70. An invited editorial accompanied the article (970-1).
Zhang M, Zhang X, Qureshi AA, Eliassen AH, Hankinson SE, Han J. Association between cutaneous nevi and breast cancer in the Nurses’ Health Study: a prospective cohort. PLoS Med. 2014 Jun 10;11(6):e1001659. An invited editorial accompanied the article (e1001661).
Wu S, Han J, Feskanich D, Cho E, Stampfer MJ, Willett WC, Qureshi AA. Citrus Consumption and Risk of Cutaneous Malignant Melanoma. J Clin Oncol. 2015 2015 Aug 10;33(23):2500-8. An invited editorial accompanied the article. 2015 Aug 10;33(23):2487-8.
Chahal H, Lin Y, Ransohoff K, Hinds DA, Wu W, Dai HJ, Qureshi AA, Li WQ, Kraft P, Tang JY, Han J*, Sarin KY* (*co-senior and co-corresponding authors). Genome-wide association study identifies novel susceptibility loci for cutaneous squamous cell carcinoma. Nat Commun. 2016 Jul 18;7:12048. doi: 10.1038/ncomms12048.
Chahal H, Wu W, Ransohoff K, Yang L, Hedlin H, Desai M, Lin Y, Dai HJ, Qureshi AA, Li WQ, Kraft P, Hinds DA, Tang JY, Han J*, Sarin KY* (*co-senior and co-corresponding authors). Genome Wide Association Study Identifies 14 Novel Risk Alleles Associated with Basal Cell Carcinoma. Nat Commun. 2016 Aug 19;7:12510. doi: 10.1038/ncomms12510.